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- Title
Long-Term Aerobic Exercise Can Potentiate the Effect of Rosiglitazone on Islet Preservation and Insulin Resistance via Increased Phosphorylation of AMPK in Diabetic Prone OLETF Rat Model.
- Authors
Piao, Shanji; Nam, Moonsuk; Park, In-Sun; Earm, Jae H.; Kim, So H.; Hong, Seong B.; Kim, Yeong S.
- Abstract
Long-term steady aerobic exercise is recommended for diabetes treatment with or without anti-diabetic medications, particularly thiazolidinediones in obese type 2 diabetes mellitus. We evaluated the effects of aerobic exercise (20 m/min, 30 minutes/day) and rosiglitazone (3mg/kg/day) for 24 weeks on islet morphology and insulin resistance in obese diabetic prone animal model, OLETF rat. Increased lean body mass, decreased epididymal fat, and improved intraperitoneal glucose tolerance test were observed in both rosiglitazone plus exercise and exercise only groups (each group n=15). And the onset of diabetes was also delayed in both exercise and rosiglitazone group compared with control. On the chronological changes of islet morphology, the more significant preservation of islet morphology and decrease of beta cell destruction were shown in rosiglitazone plus exercise group compared with exercise or rosiglitazone only. And exercise led to extension of normal expressions of insulin and GLUT-2 to the level of rosiglitazone group with western blotting and confocal microscopic finding, indicating comparable preventive or therapeutic effects of exercise with rosiglitazone treatment. The increased phosphorylation of AMPK (α, β) and increased adiponectin expression level in pancreas were observed in rosiglitazone group compared with control OLETF rat and exercise only groups with western blotting. The measured NOx (nitrite and nitrate) in pancreatic tissue were recovered in rosiglitazone only and plus exercise groups compared with control OLEFT rats. We suggest the exercise is an essential therapeutic regimen for islet preservation and improving insulin resistance in obese type 2 diabetes, particularly for anti-diabetic treatment with rosiglitazone.
- Subjects
AEROBIC exercises; TREATMENT of diabetes; HYPOGLYCEMIC agents; TYPE 2 diabetes; GLUCOSE tolerance tests; INSULIN resistance; ANIMAL disease models; LABORATORY rats
- Publication
Diabetes, 2007, Vol 56, pA276
- ISSN
0012-1797
- Publication type
Article