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- Title
Higher Bone Mineral Density in Older Men with Diabetes and Impaired Fasting Glucose: The Osteoporotic Fractures in Men Study.
- Authors
Strotmeyer, Elsa S.; Marshall, Lynn M.; Schwartz, Ann V.; Bauer, Doug C.; Lang, Thomas F.; Barrett-Connor, Elizabeth; Orwoll, Eric S.; Cauley, Jane A.
- Abstract
Type 2 diabetes (DM) is related to higher bone mineral density (BMD) in older white women, perhaps due to obesity and higher fasting insulin levels, but less data exists for men or those with impaired fasting glucose (IFG). We performed a cross-sectional analyses of 2000-02 baseline data from 5,995 community dwelling, ambulatory men aged ≥65 years from Birmingham, AL; Minneapolis, MN; Palo Alto, CA; Pittsburgh, PA; Portland, OR; and San Diego, CA in the Osteoporotic Fractures in Men (MrOS) Study. DM was defined as self-report of a diagnosis by a physician, hypoglycemic medication or fasting glucose (FG) ≥126 mg/dl; IFG was defined as FG ≥100 and < 126 mg/dl. BMD was measured by DXA (QDR 4500W, Hologic Inc) at the femoral neck and total hip and in a subset of 3207, by quantitative computerized tomography (QCT) for vertebral and femoral neck trabecular volumetric BMD (vBMD). Participants missing fasting blood draw and DM/IFG status were excluded. Of the remaining 5,556 participants (age 73.6±5.9 years; 90% white), 16% had DM and 37% had IFG. After adjustment for age, race, lean and fat mass, and fasting insulin, BMD and volumetric BMD remained 4-5% and 10-18% higher respectively in DM men and 1-2% and 5-8% higher respectively in men with IFG compared to men with normal FG for all measures (Table 1). Both diabetes and IFG were positively associated with higher BMD in these older men. Men with IFG had BMD intermediate between men with DM and normal FG. Higher lean and fat mass and higher fasting insulin levels did not account for these associations.
- Subjects
UNITED States; TYPE 2 diabetes; BLOOD sugar; HYPERGLYCEMIA; BONE density; PEOPLE with diabetes
- Publication
Diabetes, 2007, Vol 56, pA259
- ISSN
0012-1797
- Publication type
Article