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- Title
Prevalence of Metabolic Syndrome According to the Progression of Menopause in Korean Women: Relationship Between the Menstrual Stage and Metabolic Syndrome Components.
- Authors
Koh, Jang H.; Lee, Mi Y.; Nam, Soo M.; Jung, Pil M.; Lee, Il Y.; Kim, Mi J.; Shin, Jang Y.; Shin, Young G.; Chung, Choon H.
- Abstract
The prevalence of metabolic syndrome (MS) is 60% higher in postmenopausal women compared with premenopausal women. Increased total and low-density lipoprotein (LDL) cholesterol levels, decreased high-density lipoprotein (HDL) cholesterol and estrogen levels, and increased visceral obesity in postmenopausal women may be associated with the increased risk of MS. The purpose of this study was to investigate the prevalence of metabolic syndrome according to the progression of menopause and to assess relationship between the menstrual stage and metabolic syndrome components. A total of 1,926 healthy women (mean age 43.84±10.34 years; body mass index (BMI) 23.41±3.20 kg/m[sup 2]) were enrolled and divided into three groups according to their menstrual stage; premenopausal group, perimenopausal group, and postmenopausal group. The metabolic syndrome was defined using the National Cholesterol Education Program (NCEP)'s Adult Treatment Panel III criteria. The prevalence of metabolic syndrome in premenopausal, perimenopausal, and postmenopausal groups was 7.1%, 9.8%, and 24.2%, respectively (p < 0.01). Waist circumference (WC), blood pressure (BP), BMI, alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), and fasting glucose levels were significantly increased according to menstrual stage (p < 0.001). The strong positive correlation was showed between the number of MS components and WC in postmenopausal women (r=0.561, p < 0.01). Compared to premenopausal women, the odds ratios for MS and MS components in postmenopausal women were significantly increased: MS 1 vs. 4.142 (3.056-5.612); WC 1 vs. 3.763 (2.947-4.806); triglyceride 1 vs. 2.899 (2.216-3.791); HDL cholesterol 1 vs. 1.673 (1.298-2.158); BP 1 vs. 3.858 (3.049-4.811); fasting glucose 1 vs. 2.803 (2.088-3.763), respectively (95% CI, p < 0.001). The prevalence of MS was significantly increased according to progression of menopause. Increased WC may play an important role in development of MS in postmenopausal women.
- Subjects
METABOLIC syndrome; MENOPAUSE; LOW density lipoproteins; HIGH density lipoproteins; ALANINE aminotransferase; GLUCOSE; TRIGLYCERIDES; BLOOD pressure
- Publication
Diabetes, 2007, Vol 56, pA255
- ISSN
0012-1797
- Publication type
Article