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- Title
CRISPR Variants for Gene Editing in Plants: Biosafety Risks and Future Directions.
- Authors
Movahedi, Ali; Aghaei-Dargiri, Soheila; Li, Hongyan; Zhuge, Qiang; Sun, Weibo
- Abstract
The CRISPR genome editing technology is a crucial tool for enabling revolutionary advancements in plant genetic improvement. This review shows the latest developments in CRISPR/Cas9 genome editing system variants, discussing their benefits and limitations for plant improvement. While this technology presents immense opportunities for plant breeding, it also raises serious biosafety concerns that require careful consideration, including potential off-target effects and the unintended transfer of modified genes to other organisms. This paper highlights strategies to mitigate biosafety risks and explores innovative plant gene editing detection methods. Our review investigates the international biosafety guidelines for gene-edited crops, analyzing their broad implications for agricultural and biotechnology research and advancement. We hope to provide illuminating and refined perspectives for industry practitioners and policymakers by evaluating CRISPR genome enhancement in plants.
- Subjects
GENOME editing; GENETIC variation; CRISPRS; PLANT genes; BIOSAFETY
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 22, p16241
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms242216241