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- Title
Adverse Human Health Effects of Chromium by Exposure Route: A Comprehensive Review Based on Toxicogenomic Approach.
- Authors
Shin, Dong Yeop; Lee, Sang Min; Jang, Yujin; Lee, Jun; Lee, Cheol Min; Cho, Eun-Min; Seo, Young Rok
- Abstract
Heavy metals are defined as metals with relatively high density and atomic weight, and their various applications have raised serious concerns about the environmental impacts and potential human health effects. Chromium is an important heavy metal that is involved in biological metabolism, but Cr exposure can induce a severe impact on occupational workers or public health. In this study, we explore the toxic effects of Cr exposure through three exposure routes: dermal contact, inhalation, and ingestion. We propose the underlying toxicity mechanisms of Cr exposure based on transcriptomic data and various bioinformatic tools. Our study provides a comprehensive understanding of the toxicity mechanisms of different Cr exposure routes by diverse bioinformatics analyses.
- Subjects
CHROMIUM; ATOMIC weights; POISONS; GENE expression profiling
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 4, p3410
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24043410