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- Title
IL-17A Enhances Retinal Neovascularization.
- Authors
Taylor, Brooklyn E.; Lee, Chieh A.; Zapadka, Thomas E.; Zhou, Amy Y.; Barber, Katherine G.; Taylor, Zakary R. R.; Howell, Scott J.; Taylor, Patricia R.
- Abstract
Retinal neovascularization occurs in proliferative diabetic retinopathy, neovascular glaucoma, and age-related macular degeneration. This type of retinal pathology normally occurs in the later stages of these ocular diseases and is a prevalent cause of vision loss. Previously, we determined that Interleukin (IL)-17A plays a pivotal role in the onset and progression of non-proliferative diabetic retinopathy in diabetic mice. Unfortunately, none of our diabetic murine models progress to proliferative diabetic retinopathy. Hence, the role of IL-17A in vascular angiogenesis, neovascularization, and the onset of proliferative diabetic retinopathy was unclear. In the current study, we determined that diabetes-mediated IL-17A enhances vascular endothelial growth factor (VEGF) production in the retina, Muller glia, and retinal endothelial cells. Further, we determined that IL-17A can initiate retinal endothelial cell proliferation and can enhance VEGF-dependent vascular angiogenesis. Finally, by utilizing the oxygen induced retinopathy model, we determined that IL-17A enhances retinal neovascularization. Collectively, the results of this study provide evidence that IL-17A plays a pivotal role in vascular proliferation in the retina. Hence, IL-17A could be a potentially novel therapeutic target for retinal neovascularization, which can cause blindness in multiple ocular diseases.
- Subjects
RETROLENTAL fibroplasia; MACULAR degeneration; VASCULAR endothelial growth factors; NEOVASCULARIZATION; DIABETIC retinopathy; VISION disorders
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 2, p1747
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24021747