We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Enteroendocrine System and Gut Barrier in Metabolic Disorders.
- Authors
Osinski, Céline; Moret, Dounia; Clément, Karine; Serradas, Patricia; Ribeiro, Agnès
- Abstract
With the continuous rise in the worldwide prevalence of obesity and type 2 diabetes, developing therapies regulating body weight and glycemia has become a matter of great concern. Among the current treatments, evidence now shows that the use of intestinal hormone analogs (e.g., GLP1 analogs and others) helps to control glycemia and reduces body weight. Indeed, intestinal endocrine cells produce a large variety of hormones regulating metabolism, including appetite, digestion, and glucose homeostasis. Herein, we discuss how the enteroendocrine system is affected by local environmental and metabolic signals. These signals include those arising from unbalanced diet, gut microbiota, and the host metabolic organs and their complex cross-talk with the intestinal barrier integrity.
- Subjects
METABOLIC disorders; HYPERGLYCEMIA; TYPE 2 diabetes; APPETITE; BODY weight; GUT microbiome; WEIGHT loss; GLYCOLYSIS
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 7, p3732
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23073732