We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling.
- Authors
Okuyama, Tomoko; Kyohara, Mayu; Terauchi, Yasuo; Shirakawa, Jun
- Abstract
It has been well established that insulin-like growth factors (IGFs) mainly mediate long-term actions in cell fates, whereas insulin predominantly exerts its role on metabolic activity. Indeed, insulin mediates multiple anabolic biological activities in glucose and amino acid transport, lipid and protein synthesis, the induction of glycogen, the inhibition of gluconeogenesis, lipolysis, and protein degradation. The interactions and differences between insulin receptor signaling and IGF-I receptor signaling in the metabolism and the cell fates are quite complicated. Because of the overlapping actions of IGF-I singling with insulin signaling, it has been difficult to distinguish the role of both signaling mechanisms on the metabolism. Furthermore, comprehensive information on the IGF-I function in respective tissues remains insufficient. Therefore, we need to clarify the precise roles of IGF-I signaling on the metabolism separate from those of insulin signaling. This review focuses on the metabolic roles of IGFs in the respective tissues, especially in terms of comparison with those of insulin, by overviewing the metabolic phenotypes of tissue-specific IGF-I and insulin receptor knockout mice, as well as those in mice treated with the dual insulin receptor/IGF-I receptor inhibitor OSI-906.
- Subjects
METABOLIC regulation; SOMATOMEDIN; INSULIN receptors; AMINO acid transport; PROTEOLYSIS; CELL metabolism
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 13, p6817
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22136817