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- Title
Cytokine Signature of Dengue Patients at Different Severity of the Disease.
- Authors
Puc, Irwin; Ho, Tzu-Chuan; Yen, Ko-Lun; Vats, Amrita; Tsai, Jih-Jin; Chen, Po-Lin; Chien, Yu-Wen; Lo, Yu-Chih; Perng, Guey Chuen; Hattori, Toshio
- Abstract
Clinical presentations of dengue fever (DF) are diverse and non-specific, causing unpredictable progression and outcomes. Its progression and severity have been associated with cytokine levels alteration. In this study, dengue patients were classified into groups following the 2009 WHO dengue classification scheme to investigate the cytokine signature at different severity of the disease: dengue without warning sign symptoms (A); dengue with warning signs (B); severe dengue (C); other fever (OF) and healthy (Healthy). We analyzed 23 different cytokines simultaneously, namely IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-33, CD14, CD54, CD62E, CD62L, CD62p, CD106, CD121b, CD154, CD178, GM-CSF, IFN-g, MIF, ST2 and TNF from patients admitted to National Cheng Kung University Hospital during the 2015 Taiwan dengue outbreak. Cytokines TNF, CD54, CD62E, CD62L, CD62P, GM-CSF, IL-1b, IL-2, IL-6, IL-8, IL-10, IL-12p70, IL-17A, INF-g and MIF were elevated while CD106, CD154, IL-4 and L-33 were decreased when compared to the control. IL-10 demonstrated to be a potential diagnostic marker for DF (H and A group; AUC = 0.944, H and OF group; AUC = 0.969). CD121b demonstrated to be predictive of the SD (A and B group; AUC = 0.744, B and C group; AUC = 0.775). Our results demonstrate the cytokine profile changes during the progression of dengue and highlight possible biomarkers for optimizing effective intervention strategies.
- Subjects
TAIWAN; CYTOKINES; DENGUE; DENGUE hemorrhagic fever; VASCULAR cell adhesion molecule-1; INTERLEUKIN-1; SYMPTOMS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 6, p2879
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22062879