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- Title
Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases.
- Authors
Vega-Rubín-de-Celis, Silvia; Kinch, Lisa; Peña-Llopis, Samuel
- Abstract
Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications. Several studies indicate that receptor and non-receptor tyrosine kinases regulate autophagy activity in cancer, and some suggest the importance of Beclin 1 tyrosine phosphorylation in this process. Here we summarize the current knowledge of the mechanism whereby some oncogenic tyrosine kinases regulate autophagy through Beclin 1.
- Subjects
AUTOPHAGY; KINASES; TYROSINE; POST-translational modification; PHOSPHATIDYLINOSITOL 3-kinases
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 23, p9210
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21239210