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- Title
Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome.
- Authors
Qu, Xianqin; Donnelly, Richard
- Abstract
Human sex hormone-binding globulin (SHBG) is a glycoprotein produced by the liver that binds sex steroids with high affinity and specificity. Clinical observations and reports in the literature have suggested a negative correlation between circulating SHBG levels and markers of non-alcoholic fatty liver disease (NAFLD) and insulin resistance. Decreased SHBG levels increase the bioavailability of androgens, which in turn leads to progression of ovarian pathology, anovulation and the phenotypic characteristics of polycystic ovarian syndrome (PCOS). This review will use a case report to illustrate the inter-relationships between SHBG, NAFLD and PCOS. In particular, we will review the evidence that low hepatic SHBG production may be a key step in the pathogenesis of PCOS. Furthermore, there is emerging evidence that serum SHBG levels may be useful as a diagnostic biomarker and therapeutic target for managing women with PCOS.
- Subjects
POLYCYSTIC ovary syndrome; FATTY liver; BIOMARKERS; GLOBULINS; INDUCED ovulation; INSULIN resistance
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 21, p8191
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21218191