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- Title
Graphene Oxide Scaffold Stimulates Differentiation and Proangiogenic Activities of Myogenic Progenitor Cells.
- Authors
Wierzbicki, Mateusz; Hotowy, Anna; Kutwin, Marta; Jaworski, Sławomir; Bałaban, Jaśmina; Sosnowska, Malwina; Wójcik, Barbara; Wędzińska, Aleksandra; Chwalibog, André; Sawosz, Ewa
- Abstract
The physiological process of muscle regeneration is quite limited due to low satellite cell quantity and also the inability to regenerate and reconstruct niche tissue. The purpose of the study was to examine whether a graphene oxide scaffold is able to stimulate myogenic progenitor cell proliferation and the endocrine functions of differentiating cells, and therefore, their active participation in the construction of muscle tissue. Studies were carried out using mesenchymal cells taken from 6-day-old chicken embryos and human umbilical vein endothelial cells (HUVEC) were used to assess angiogenesis. The graphene scaffold was readily colonized by myogenic progenitor cells and the cells dissected from heart, brain, eye, and blood vessels did not avoid the scaffold. The scaffold strongly induced myogenic progenitor cell signaling pathways and simultaneously activated proangiogenic signaling pathways via exocrine vascular endothelial growth factor (VEGF) secretion. The present study revealed that the graphene oxide (GO) scaffold initiates the processes of muscle cell differentiation due to mechanical interaction with myogenic progenitor cell.
- Subjects
PROGENITOR cells; MYOBLASTS; GRAPHENE oxide; VASCULAR endothelial growth factors; SATELLITE cells; HUMAN embryos
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 11, p4173
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21114173