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- Title
Cross-Reactivity of Palladium in a Murine Model of Metal-induced Allergic Contact Dermatitis.
- Authors
Shigematsu, Hiroaki; Kumagai, Kenichi; Suzuki, Motoaki; Eguchi, Takanori; Matsubara, Ryota; Nakasone, Yasunari; Nasu, Keisuke; Yoshizawa, Takamasa; Ichikawa, Haruno; Mori, Takahiro; Hamada, Yoshiki; Suzuki, Ryuji
- Abstract
Metal allergy is usually diagnosed by patch testing, however, the results do not necessarily reflect the clinical symptoms because of cross-reactivity between different metals. In this study, we established the novel mouse model of cross-reactive metal allergy, and aimed to elucidate the immune response in terms of T-cell receptor repertoire. This model was classified into two groups: the sensitization to nickel and challenge with palladium group, and the sensitization to chromium and challenge with palladium group. This model developed spongiotic edema with intra- and peri-epithelial infiltration of CD4+ T cells in the inflamed skin that resembles human contact dermatitis. Using T cell receptor analysis, we detected a high proportion of T cells bearing Trav8d-1-Traj49 and Trav5-1-Traj37 in the Ni- and Cr-sensitized Pd-challenged mice. Furthermore, mucosal-associated invariant T cells and invariant natural killer T cells were also detected. Our results indicated that T cells bearing Trav8d-1-Traj49 and Trav5-1-Traj37 induced the development of palladium-cross reactive allergy, and that mucosal-associated invariant T and invariant natural killer T cells were also involved in the cross-reactivity between different metals.
- Subjects
CYTOTOXIC T cells; KILLER cells; PALLADIUM; CONTACT dermatitis; CELL analysis; T cell receptors; T cells; IMMUNOGLOBULIN E
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 11, p4061
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21114061