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- Title
Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a Korean Population.
- Authors
Yoonsun Bae; Dongjik Shin; Jiho Nam; Hye Rim Lee; Jun Sung Kim; Kyu Yeun Kim; Dong Soo Kim; Yeun-Jun Chung
- Abstract
Purpose: Kawasaki disease (KD) is a mucocutaneous lymph node syndrome. It is mainly seen in young children under the age of five. KD is a multifactorial disorder that includes genetic variants. The present study investigated the association between KD and single nucleotide polymorphisms (SNPs) in the candidate gene early B cell factor 2 (EBF2), which is associated with inflammation markers. Materials and Methods: An SNP analysis was performed by whole exon sequencing of the EBF2 gene. Our study comprised a total of 495 subjects (295 KD patients and 200 unrelated normal controls) from a Korean population. Tag SNPs were discovered using the Haploview program. Genotyping of the EBF2 gene was performed with the TaqMan® assay with real-time PCR methods. Results: Polymorphism of rs10866845 showed a significant difference in allele frequency between KD patients and controls (p=0.040). The EBF2 gene polymorphisms were significantly associated with KD on logistic regression analysis. Conclusion: EBF2 gene variants can contribute to KD in the Korean population.
- Subjects
MUCOCUTANEOUS lymph node syndrome; GENETIC polymorphisms; SINGLE nucleotide polymorphisms; B cells; INFLAMMATION
- Publication
Yonsei Medical Journal, 2018, Vol 59, Issue 4, p519
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2018.59.4.519