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- Title
Convenient and Efficient Synthesis of 11-Amino-2,8-substituted-2,3,8,9-tetrahydrobenzo[4,5]thieno[2,3- b]quinolinone Derivatives.
- Authors
Wang, Zhong ‐ Xia; Chen, Li ‐ Zhuang; Li, Bei; Han, Guang ‐ Fan
- Abstract
The Gewald reactions of 5-substituted-1,3-cyclohexanedione, malononitrile, and powdered sulfur were carried out to give the corresponding products 2-amino-5-substituted-7-oxo-4,5,6,7-tetrahydrobenzo[ b]thiophene-3-carbonitrile derivatives 1. The enamines 2 were prepared by reaction of compounds 1 and 5-substituted-1,3-cyclohexanedione with as catalyst. The title compounds 11-amino-2,8-substituted-2,3,8,9-tetrahydrobenzo[4,5]thieno[2,3- b]quinolinone 3 were synthesized by of compounds 2 in the presence of K2CO3 and Cu2Cl2. The structures of all compounds were characterized by elemental analysis, IR, MS, and 1H-NMR spectra.
- Subjects
CHEMICAL synthesis; CARBONITRILES; MALONONITRILE; CHEMICAL derivatives; CHEMICALS
- Publication
Journal of Heterocyclic Chemistry, 2015, Vol 52, Issue 6, p1663
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.2200