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- Title
Synthesis of Pyrimidine, Dihydropyrimidinone, and Dihydroimidazole Derivatives under Free Solvent Conditions and Their Antibacterial Evaluation.
- Authors
Soliman, Ahmed M.; Mohamed, Shaaban K.; El ‐ Remaily, Mahmoud. Abd El Aleem. Ali. Ali.; Abdel ‐ Ghany, H.
- Abstract
The compounds of pyrimidine, dihydropyrimidinone, and dihydroimidazole have been synthesized in excellent yield under free solvent conditions. The antibacterial evaluation of the products showed a high inhibitory effect. Reaction of 2-guanidinobenzothiazole with several active methylene compounds has revealed formation of the corresponding pyrimidine, dihydropyrimidinone, and dihydroimidazole derivatives under free solvent conditions in very good yield. All compounds have been characterized on the basis of IR, 1H NMR, 13C NMR, , and X-ray.
- Subjects
PYRIMIDINE derivatives; CHEMICAL synthesis; IMIDAZOLES; SOLVENTS; METHYLENE group; ANTIBACTERIAL agents
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, Issue 4, p1202
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1657