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- Title
Exposure to atrazine and endosulfan alters oviductal adenogenesis in the broad-snouted caiman (Caiman latirostris).
- Authors
Tavalieri, Yamil; Alarcón, Ramiro; Tschopp, María; Luque, Enrique; Muñoz-de-Toro, Mónica; Galoppo, Germán
- Abstract
The molecular pathways involved in oviductal adenogenesis are highly conserved among vertebrates. In this work, we study the histomorphological changes and molecular pathways involved in Caiman latirostris oviductal adenogenesis and the effects of in ovo exposure to environmentally relevant doses of endosulfan (END) and atrazine (ATZ) on these processes. To this end, the histomorphological changes at epithelial and subepithelial compartments, the protein expressions of β-catenin and Wnt-7a, and the gene expression of metalloproteinases (MMPs) and its inhibitors (TIMPs) were evaluated as biomarkers of oviductal adenogenesis in prepubertal juvenile C. latirostris. Exposure to END altered adenogenesis-related epithelium characteristics and mRNA expression of MMP2, MMP9, and TIMP1. Exposure to ATZ increased the width of the subepithelial stroma with loosely arranged collagen fibers and increased β-catenin expression in buds (invaginated structures that precede glands). The results demonstrate that in ovo exposure to ATZ and END alters oviductal adenogenesis at tissue, cellular, and molecular levels. An altered oviductal adenogenesis could impair fertility, raising concern on the effects of pesticide pollution in wildlife and domestic animals.
- Subjects
ATRAZINE; ENDOSULFAN; FALLOPIAN tubes; PESTICIDE pollution; GENE expression; PROTEIN expression; DOMESTIC animals
- Publication
Environmental Science & Pollution Research, 2024, Vol 31, Issue 24, p35927
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-024-33662-7