We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacokinetics of oxytetracycline in hybrid catfish (Clarias macrocephalus x C. gariepinus) after intravascular and oral administrations.
- Authors
Amnart Poapolathep; Kednapat Sriphairoj; Sittichai Hatachote; Kannika Wongpanit; Duangkamol Saensawath; Narumol Klangkaew; Napasorn Phaochoosak; Giorgi, Mario; Saranya Poapolathep
- Abstract
Importance: Over the past decade, catfish farming has increased in Southeast Asia. However, there has been no existing for pharmacokinetic data in the hybrid catfish ( Clarias macrocephalus x C. gariepinus). Objective: This study was designed to evaluate the pharmacokinetic characteristics of oxytetracycline (OTC) in the hybrid catfish, following single intravascular (IV) or oral (PO) administration at a single dosage of 50 mg/kg body weight (BW). Methods: In total, 140 catfish (each about 100-120 g BW) were divided into two groups (n = 70). Blood samples (0.6-0.8 mL) were collected from ventral caudal vein at pre-assigned times up to 144 h (sparse samples design). OTC plasma concentrations were analyzed using high-performance liquid chromatography-photodiode array detector. Results: The pharmacokinetic parameter of OTC was evaluated using a non-compartment model. OTC plasma concentrations were detectable for up to 144 and 120 h after IV and PO, respectively. The elimination half-life value of OTC was long with slow clearance after IV administration in hybrid catfish. The average maximum concentration value of OTC was 2.72 µg/mL with a time at the maximum concentration of 8 h. The absolute PO bioavailability was low (2.47%). Conclusions and Relevance: These results showed that PO administration of OTC at a dosage of 50 mg/kg BW was unlikely to be effective for clinical use in catfish. The pharmacodynamic properties and clinical efficacy of OTC after multiple medicated feed are warranted.
- Subjects
ORAL drug administration; AGRICULTURE; ANIMAL feeds; CATFISHES; BODY weight
- Publication
Journal of Veterinary Science, 2024, Vol 25, Issue 4, p1
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.24118