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- Title
Effect of alcohol on blood glucose and antioxidant enzymes in the liver and kidney of diabetic rats.
- Authors
Shanmugam, K. R.; Mallikarjuna, K.; Sathyavelu Reddy, K.
- Abstract
Objective: Diabetes mellitus affects every organ in the man including eyes, kidney, heart, and nervous system. Alcohol consumption is a widespread practice. As the effects of chronic alcohol consumption on diabetic state have been little studied, this study was conducted with the objective of evaluating the effect of alcohol in diabetic rats. Materials and Methods: For this study, the rats were divided into five groups (n = 6 in each group): normal control (NC), alcohol treatment (At), diabetic control (DC), diabetic plus alcohol treatment (D + At), diabetic plus glibenclamide treatment (D + Gli). Alcohol treatment was given to the diabetic rats for 30 days. During the period the blood glucose levels, and body weight changes were observed at regular intervals. The antioxidantenzymes like superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels were assayed in the liver and kidney tissues. Results: The blood glucose levels were significantly (P < 0.001) elevated and body weightsignificantly (P < 0.001) decreased in alcohol-treated diabetic rats. SOD and CAT activities were decreased and the MDA level increased significantly (P < 0.001) in alcohol-treateddiabetic rats. Histopathological studies showed that alcohol damages the liver and kidney tissues in diabetic rats. Conclusion: These finddings concluded that the consumption of alcohol in diabeticrats worsens the condition. So the consumption of alcohol by diabetic subjects may be potentially harmful.
- Subjects
DIABETES; LABORATORY mice; BLOOD sugar; ANTIOXIDANTS; ALCOHOL drinking; LIVER physiology; KIDNEY physiology
- Publication
Indian Journal of Pharmacology, 2011, Vol 43, Issue 3, p330
- ISSN
0253-7613
- Publication type
Article
- DOI
10.4103/0253-7613.81504