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- Title
Gene expression profile changes correlated with lymph node metastasis in oral squamous cell carcinoma.
- Authors
Kashiwazaki, Haruhiko; Monsur Hassan, Nur Mohammad; Hamada, Jun-ichi; Moriuchi, Tetsuya; Yamazaki, Yutaka; Tei, Kanchu; Totsuka, Yasunori; Inoue, Nobuo
- Abstract
The purpose of this research was to identify biomarkers for predicting cervical lymph node metastasis in oral squamous cell carcinoma (OSCC). We surveyed the expressions of 1289 cancer-related genes in 41 cases of OSCC by cDNA array analysis. We extracted genes upregulated or downregulated in their expression in association with lymph node metastasis. Of 1289 cancer-related genes, we identified 39 genes differentially expressed in OSCC with or without lymph node metastasis. Expression levels of 9 genes were lower, and those of 30 genes were higher, in node-positive cases. The genes expressed at higher levels in node-positive cases included angiogenesis-related molecules, cell adhesion molecules, and proteolytic enzymes. We suggest that these characteristic genes could provide, if verifiable, useful information for predicting the risk of lymph node metastasis in OSCC.
- Subjects
GENE expression; SQUAMOUS cell carcinoma; LYMPH nodes; METASTASIS; ORAL cancer
- Publication
Odontology, 2008, Vol 96, Issue 1, p38
- ISSN
1618-1247
- Publication type
Article
- DOI
10.1007/s10266-008-0084-1