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- Title
Biomimetic Formation of Macrocyclic Spermine Alkaloids.
- Authors
Dimitrov, Vladimir; Geneste, Hervé; Guggisberg, Armin; Hesse, Manfred
- Abstract
Dihydroxyverbacine ( 10), a precursor for oxidative phenol coupling, was obtained via (±)-buchnerine ( 14), whose synthesis is described. The oxidizing system hemin (ferriprotoporphyrin IX chloride)/H2O2 promoted intramolecular coupling of 10 to give the alkaloids aphelandrine ( 1), orantine ( 2), and chaenorpine ( 7). The alkaloids were identified by on-line coupled HPLC and atmospheric-pressure chemical-ionization (APCI) mass spectrometry.
- Publication
Helvetica Chimica Acta, 2001, Vol 84, Issue 7, p2108
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/1522-2675(20010711)84:7<2108::AID-HLCA2108>3.0.CO;2-G