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- Title
Lymph node involvement by enteropathy-like indolent NK-cell proliferation.
- Authors
Dargent, Jean-Louis; Tinton, Nicolas; Trimech, Mounir; de Leval, Laurence
- Abstract
Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein–Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointestinal (GI) tract as their designations implies, a few cases have been reported outside the GI tract. We hereby describe a unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis. The histologic, phenotypic, and molecular features of this NK-cell proliferation, which were very similar if not identical to those previously reported in NKCE or LG, suggest that similar indolent EBV-negative NK-cell LPDs may also occasionally involve lymph nodes.
- Subjects
LYMPH nodes; LYMPHOPROLIFERATIVE disorders; GASTROINTESTINAL system; GALLBLADDER; EPSTEIN-Barr virus; PHENOTYPES
- Publication
Virchows Archiv: European Journal of Pathology, 2021, Vol 478, Issue 6, p1197
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-020-02892-8