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- Title
In-vitro and in-vivo immunomodulatory effects of syringin.
- Authors
Cho, Jae Youl; Nam, Kwon Ho; Kim, Ae Ra; Park, Jisoo; Yoo, Eun Sook; Baik, Kyong Up; Yu, Young Hyo; Park, Myung Hwan
- Abstract
Syringin was found to possess immunomodulatory activity by which it inhibited the in-vitro immunohaemolysis of antibody-coated sheep erythrocytes by guinea-pig serum through suppression of C3-convertase of the classical complement. In this study, we examined its in-vitro and in-vivo activity on tumour necrosis factor (TNF)-α and nitric oxide (NO) production, CD4 + T cell and CD8+ cytotoxic T cell (CTLL-2) proliferation, and croton oil-, arachidonic acid- and fluorescein-isothiocynate (FITC)-induced mouse ear oedema model. Syringin significantly inhibited both TNF-α production from lipopolysaccharide (LPS)-stimulated RAW264.7 cells and CD8+ T cell (CTLL-2) proliferation in a dose-dependent manner, whereas neither NO production nor CD4+ T cell proliferation were blocked even by high concentrations of syringin. In the in-vivo experiments, syringin also significantly suppressed FITC-induced ear oedema in mice but not the ear oedema induced by croton or arachidonic acid. These results suggest that syringin may be implicated as an immunomodulator having an anti-allergic effect rather than an antiinflammatory effect. The anti-allergic effect of syringin seems to be due, in part, to inhibition of TNF-α production and cytotoxic T cell proliferation.
- Publication
Journal of Pharmacy & Pharmacology, 2001, Vol 53, Issue 9, p1287
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1211/0022357011776577