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- Title
Evaluation of the efficacy of botulinum toxin pretreatment for the management of radiotherapy-induced salivary gland dysfunction.
- Authors
Hebish, Houssam H.; Megahed, Eman M.; Raghib, Adel M.
- Abstract
Background: Salivary glands intensively deteriorate when exposed to radiotherapy with a resultant reduction in saliva production and developing xerostomia-associated complications. Botox, a commercially available botulinum neurotoxin A performs chemical denervation and degranulation of salivary acinar cells. Objective: To investigate, histopathologically, whether pretreatment botulinum toxin could potentially protect the gland cells from the deleterious effects of ionizing radiation. Material and methods: Twenty male Wistar rats were randomly assigned into two equal groups. Submandibular salivary glands were intraglandularly injected by either 2.5 U of botulinum in one group or an equal amount of saline in the other group before being exposed locally to 15 Gy of Cs137 γ-irradiation. Thirty days later, glands were harvested for histopathological assessment and calculation of acinar surface area. Results: Botulinum-injected glands retained a near normal acinar architecture better than the saline group that showed marked serous atrophy and degeneration. Ductal and mucous cells were more radioresistant. A statistically significant difference existed between both groups in regards to serous acinar surface area P value less than 0.05. Conclusion: Botulinum neurotoxin protected murine salivary gland acinar cells from ionizing radiation.
- Subjects
BOTULINUM toxin; SALIVARY gland diseases; IONIZING radiation; SURFACE area; HISTOPATHOLOGY
- Publication
Tanta Dental Journal, 2023, Vol 20, Issue 3, p242
- ISSN
1687-8574
- Publication type
Article
- DOI
10.4103/tdj.tdj_21_23