We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Resolution of protected silaproline for a gram scale preparation.
- Authors
Martin, C.; Vanthuyne, N.; Miramon, H.; Martinez, J.; Cavelier, F.
- Abstract
Silaproline is an analogue of proline, which exhibits similar conformational properties. Moreover, the presence of dimethylsilyl group confers to silaproline a higher lipophilicity as well as an improved resistance to biodegradation. This report describes the comparison of two routes to obtain Fmoc-( l) Sip-OH on the gram scale using chiral HPLC resolution.
- Subjects
PROLINE; CONFORMATIONAL analysis; BIODEGRADATION; CHIRALITY; METHYLSILYL compounds; HIGH performance liquid chromatography; ENANTIOMERS
- Publication
Amino Acids, 2012, Vol 43, Issue 2, p649
- ISSN
0939-4451
- Publication type
Article
- DOI
10.1007/s00726-011-1112-y