We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Long-Term Behavior of Secretory Immunity in Ileocecal and Ileal Orthotopic Neobladders.
- Authors
d’Addessi, Alessandro; Racioppi, Marco; Fanasca, Angelo; Menchinelli, Paolo; Alcini, Antonio; Delicato, Giampaolo; Alcini, Eugenio; Scuderi, Flavia
- Abstract
Objective: To compare secretory immunity in cecal and ileal orthotopic neobladders, and to detect its permanence over time. Patients and Methods: IgA was studied in the urine of 33 patients with ileocecourethrostomy (ICUS) and 13 patients with ileal reservoir (IR). The mean follow-up was 55 months. Results were compared in terms of the type of operation, a healthy control group, and the time since surgery. Results: Urinary IgA levels were significantly higher in ICUS and IR patients than in normal controls. No significant differences in IgA concentrations were detected in patients with different reservoirs and with regard to time. Conclusion: Both the reservoirs maintain the function of producing IgA. In particular no differences were detected over time and urine could be a permanent antigenic stimulus. IgA could be considered an adjunctive factor for upper urinary tract protection. For this reason we prefer to use a simple, indirect antireflux mechanism, thus avoiding direct manipulation of the uretero-intestinal anastomosis.Copyright © 2001 S. Karger AG, Basel
- Subjects
IMMUNITY; IMMUNOGLOBULIN A; RESTORATIVE proctocolectomy; BLADDER; IMMUNOLOGY
- Publication
Urologia Internationalis, 2001, Vol 67, Issue 1, p41
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000050942