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- Title
Blood Glucose Lowering Effect of Lagerstroemia speciosa L. Leaves Extract on Type 2 Diabetic Rat Model.
- Authors
Kien, Dang X.; Ha, Dinh V.; Kien, Pham T.; Huy, Truong H. A.; Nga, Nguyen T.; Dung, Vu M.; Toan, Trinh D.; Anh, Nguyen P.; Ngan, Nguyen H.
- Abstract
Lagerstroemia speciosa (Lythraceae), commonly known as banaba, is a plant native to the tropical regions of Southeast Asia that thrives abundantly in Vietnam and has been historically utilized in traditional medicine. Despite evidence suggesting that its leaves have anti-diabetic properties, studies investigating the effects of L. speciosa extracts on animal models of type 2 diabetes remain limited. Herein, the effect of dry extract from L. speciosa leaves (VLDE) collected in Vietnam on blood glucose in type 2 diabetic rats was evaluated. White rats were divided into five groups, each comprising 10 rats. Group 1 served as the non-diabetic control, receiving distilled water, while type 2 diabetes was induced in other groups with a high-fat diet and low-dose streptozotocin. Group 3 received gliclazide at a dose of 20 mg/kg/day as the positive control, whereas groups 4 and 5 were administered VLDE at doses of 620 mg/kg/day and 1240 mg/kg/day, respectively, for a treatment duration of 28 days. Blood glucose levels, blood insulin levels, and insulin resistance indices were evaluated pre-and post-treatment. VLDE at both doses demonstrated significant blood glucose-lowering effects, accompanied by a reduction in the HOMA-IR index and elevation in the HOMA-β, QUICKI, and DI indices, as well as an increase in the pancreatic mass-to-body weight ratio, comparable to the gliclazidetreated group. Our findings underscore the potential of L. speciosa extract as a medicinal therapeutic agent for type 2 diabetes management, warranting further pre-clinical and clinical validation for pharmaceutical development.
- Subjects
BLOOD sugar; LAGERSTROEMIA; TYPE 2 diabetes; PLANT extracts; PHARMACOLOGY; ANTIOXIDANTS; PHYTOCHEMICALS
- Publication
Tropical Journal of Natural Product Research, 2024, Vol 8, Issue 7, p7709
- ISSN
2616-0684
- Publication type
Article
- DOI
10.26538/tjnpr/v8i7.13