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- Title
EFFICACY OF INDIGENOUS DRUGS AGAINST ETHINYL OESTRADIOL ALTERED TRANSAMINASE ACTIVITY.
- Authors
Sharma, Madhuri; Sahni, Y. P.; Pandey, G.
- Abstract
Ethinyl oestradiol (EO) is a semisynthetic highly potent oestrogen. The excessive use of EO can cause severe cytotoxicity, including cancer. However, several indigenous drugs (herbal drugs) can act against such untoward effects. The plant-drug, ProImmu elicited immunomodulatory effect and restored normal histoarchitecture of damaged tissues. In the present study, the beneficial effects of ProImmu and its two ingredients, viz. Tinospora cordifolia and Withania somnifera were found against EO altered transaminase activity in female albino rats. The activities of two transaminases, viz. serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) were increased significantly after administration of EO @ 250 µg/kg, orally, thrice a week for 8 and 12 weeks. After 8 weeks of daily oral administration of ProImmu (@ 150 mg/kg), T. cordifolia (@ 250 mg/kg) and W. somnifera (@ 250 mg/kg), the activities of SGOT and SGPT could be significantly normalized. However, after 8 weeks of daily oral administration of these indigenous drugs at the same dose rate also brought the normalcy of SGOT and SGPT, but to lesser extent than observed after the 8 week.
- Subjects
ESTRADIOL; DRUG efficacy; ORAL drug administration; WITHANIA somnifera; TINOSPORA cordifolia; ESTROGEN
- Publication
Journal of Experimental Zoology India, 2022, Vol 25, Issue 2, p2469
- ISSN
0972-0030
- Publication type
Article