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- Title
Cell signalling: Crystallizing active arrestins.
- Authors
Wrighton, Katharine H.
- Abstract
The article reviews the study that evaluates the differences between the inactive and active forms of arrestins. It observes conformational changes that occur upon arrestin activation, all of which have previously been implicated in the activation of arrestins and their interaction with G protein-coupled receptors (GPCRs). It suggests that arrestins are activated by a common mechanism and pave the way for further structural studies.
- Subjects
MEMBRANE proteins; G proteins; ARRESTINS; G protein coupled receptors; CELL receptors
- Publication
Nature Reviews Molecular Cell Biology, 2013, Vol 14, Issue 6, p326
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3592