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- Title
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR.
- Authors
Calkin, Anna C.; Tontonoz, Peter
- Abstract
Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to metabolic pathways within the body. Given that modulation of lipid and glucose metabolism has been linked to diseases including type 2 diabetes, obesity and atherosclerosis, a greater understanding of pathways that regulate metabolism in physiology and disease is crucial. The liver X receptors (LXRs) and the farnesoid X receptors (FXRs) are activated by oxysterols and bile acids, respectively. Mounting evidence indicates that these nuclear receptors have essential roles, not only in the regulation of cholesterol and bile acid metabolism but also in the integration of sterol, fatty acid and glucose metabolism.
- Subjects
GENETIC transcription; NUCLEAR receptors (Biochemistry); METABOLISM; FARNESOID X receptor; OXYSTEROLS; BILE acids; FATTY acids
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 4, p213
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3312