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- Title
Walking to work: roles for class V myosins as cargo transporters.
- Authors
Hammer, John A.; Sellers, James R.
- Abstract
Cells use molecular motors, such as myosins, to move, position and segregate their organelles. Class V myosins possess biochemical and structural properties that should make them ideal actin-based cargo transporters. Indeed, studies show that class V myosins function as cargo transporters in yeast, moving a range of organelles, such as the vacuole, peroxisomes and secretory vesicles. There is also increasing evidence in vertebrate cells that class V myosins not only tether organelles to actin but also can serve as short-range, point-to-point organelle transporters, usually following long-range, microtubule-dependent organelle transport.
- Subjects
MYOSIN; CELL fractionation; CYTOSKELETAL proteins; MOLECULAR rotation of proteins; YEAST physiology; PEROXISOMES; VESICLES (Cytology)
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 1, p13
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3248