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- Title
Regulatory roles of natural antisense transcripts.
- Authors
Faghihi, Mohammad Ali; Wahlestedt, Claes
- Abstract
Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.
- Subjects
CYTOLOGICAL research; ANIMAL genome mapping; GENOMICS; ANTISENSE peptides; HAPLOIDY
- Publication
Nature Reviews Molecular Cell Biology, 2009, Vol 10, Issue 9, p637
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2738