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- Title
Randomized controlled trial on the efficacy of new alcohol-free chlorhexidine mouthrinses after 8 weeks.
- Authors
Zimmer, S; Korte, P; Verde, P; Ohmann, C; Naumova, E; Jordan, RA
- Abstract
Objectives To evaluate the efficacy of two alcohol-free antimicrobial mouthrinses in reducing plaque and gingivitis compared to an alcohol-containing rinse and toothbrushing alone. Methods One hundred and sixty healthy volunteers were enrolled in the randomized controlled trial. Participants were randomly and equally assigned to four groups: (i) toothbrushing + rinsing (0.06% CHX + 0.025% NaF, alcohol-containing rinse, positive control); (ii) toothbrushing + rinsing (0.06% CHX + 0.025% NaF, alcohol-free experimental rinse); (iii) toothbrushing + rinsing (0.06% CHX + 0.03% CPC + 0.025% NaF, alcohol-free experimental rinse); (iv) toothbrushing alone (negative control). At baseline, Quigley-Hein plaque index ( QHI), modified proximal plaque index ( MPPI), and papillary bleeding index ( PBI) were recorded. All subjects brushed their teeth as usual during the study. Additionally, groups 1-3 rinsed twice daily. Eight weeks after baseline, indices were recorded again. anova with Bonferroni adjustment served for statistical analysis. Results One hundred and fifty-five participants were included into final analysis (i: n = 39, 2: n = 39, 3: n = 37, 4: n = 40). Experimental rinses (ii, iii) reduced QHI and MPPI to a higher extent than the negative control (iv), whereas no significant difference to the positive control was found. QHI: (i) 36.6%, (ii) 32.3%, (iii) 36.8%, (iv) 21.6%; MPPI: (i) 11.9%, (ii) 12.2%, (iii) 13.6%, (iv) 3.5%. For PBI, no statistically significant difference was found between groups: (i) 80.2%, (ii) 77.8%, (iii) 76.5% and (iv) 78.8%. Conclusions With respect to QHI and MPPI, toothbrushing in combination with any rinse was more effective than toothbrushing alone. No statistically significant differences were found between the alcohol-free and the alcohol-containing control rinses.
- Subjects
DENTAL plaque; GINGIVITIS; MOUTHWASHES; ANALYSIS of variance; CHI-squared test; CHLORHEXIDINE; RESEARCH funding; STATISTICS; TOOTH care &; hygiene; LOGISTIC regression analysis; DATA analysis; RANDOMIZED controlled trials; BLIND experiment; DESCRIPTIVE statistics; PREVENTION; THERAPEUTICS
- Publication
International Journal of Dental Hygiene, 2015, Vol 13, Issue 2, p110
- ISSN
1601-5029
- Publication type
Article
- DOI
10.1111/idh.12111