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- Title
Distribution frequency of hepatitis C virus genotypes in 2231 patients in Iran.
- Authors
Keyvani, Hossein; Alizadeh, Amir H. M.; Alavian, Seyed M.; Ranjbar, Mitra; Hatami, Saeed
- Abstract
Aim: Given the importance of frequency distribution of HCV genotypes, we studied genotypic distribution of HCV in Iran. In this cross-sectional study, 2231 patients with hepatitis C who presented in hepatitis clinics in Tehran were investigated for HCV genotypes. Methods: Genotyping was performed by genotype specific primers. Results: The highest frequency was for genotype 1a, with 886 (39.7%) of subjects. Genotype 3a and 1b were the other frequent genotypes, with 613 (27.5%) and 271 (12.1%) subjects, respectively. Of the samples, 401 (18%) had an undetermined genotype. Mixed genotypes were also found in 33 samples (1.6%). Genotype 1b frequency in patients under 20 years old was 10.2%, while its frequency in patients over 60 years old was 18.5%. Genotype 1b frequency significantly increased by age ( P = 0.02). Conclusion: This study indicates that the dominant HCV genotype among patients living in Tehran was 1a.
- Subjects
TEHRAN (Iran); IRAN; HEPATITIS C virus; HEPATITIS viruses; FLAVIVIRUSES; VIRAL hepatitis
- Publication
Hepatology Research, 2007, Vol 37, Issue 2, p101
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1111/j.1872-034X.2007.00015.x