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- Title
In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity.
- Authors
Bartlett, Elizabeth A.; Yttredahl, Ashley A.; Boldrini, Maura; Tyrer, Andrea E.; Hill, Kathryn R.; Ananth, Mala R.; Milak, Matthew S.; Oquendo, Maria A.; Mann, J. John; DeLorenzo, Christine; Parsey, Ramin V.
- Abstract
Background. Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT1AR) binding potential, especially in the raphe nuclei, has been shown to be a trait associated with major depression, we did not replicate this finding in an independent sample using the partial agonist positron emission tomography tracer [11C]CUMI-101. Evidence suggests that CA can induce long-lasting changes in expression of 5-HT1AR, and thus, a history of CA may explain the disparate findings. Methods. Following up on our initial report, 28 unmedicated participants in a current depressive episode (bipolar n = 16, unipolar n = 12) and 19 non-depressed healthy volunteers (HVs) underwent [11C]CUMI-101 imaging to quantify 5-HT1AR binding potential. Participants in a depressive episode were stratified into mild/moderate and severe CA groups via the Childhood Trauma Questionnaire. We hypothesized higher hippocampal and raphe nuclei 5-HT1AR with severe CA compared with mild/moderate CA and HVs. Results. There was a group-by-region effect (p = 0.011) when considering HV, depressive episode mild/moderate CA, and depressive episode severe CA groups, driven by significantly higher hippocampal 5-HT1AR binding potential in participants in a depressive episode with severe CA relative to HVs (p = 0.019). Contrary to our hypothesis, no significant binding potential differences were detected in the raphe nuclei (p-values > 0.05). Conclusions. With replication in larger samples, elevated hippocampal 5-HT1AR binding potential may serve as a promising biomarker through which to investigate the neurobiological link between CA and depression.
- Subjects
SEROTONIN receptors; RAPHE nuclei; POSITRON emission tomography; HIPPOCAMPUS (Brain); CARNOSIC acid; MENTAL depression; HYPOMANIA
- Publication
European Psychiatry, 2023, Vol 66, Issue 1, p1
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1192/j.eurpsy.2023.4