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- Title
Design, Synthesis and Preliminary Pharmacological Evaluation of Mutual Prodrug of Non Steroidal AntiInflammatory Drugs Coupling with Natural AntiOxidants.
- Authors
AZIZ ALIBEG, AMMAR ABDUL; HASAN, SAMER A.; HUSSEIN, AHMAD K.; NASSER, NOOR H.; AZIZ ALIBEG, KARRAR ABDIL
- Abstract
Non steroidalanti inflammatory drugs NSAIDs Etodolac and tolmetin drugs have been coupled with varies natural antioxidants having antiulcerogenicpropertiesin order to get mutual prodrug consist of NSAIDs & antioxidant as a safer NSAIDs without gastrointestinal side-effects. The designated pro-drugs are well studied to explain their anti inflammatory, anti ulcer and analgesic activity. The mutual prodrug shows the same activity as anti inflammatory with decrease ulcerogenecity. The study results show that the mutual prodrug of NSAIDs antioxidant has the strength to create new NSAIDs with decreased undesirable adverse effects.
- Subjects
ANTIOXIDANTS; PRODRUGS; ETODOLAC; TOLMETIN; PEPTIC ulcer
- Publication
International Journal of Pharmaceutical Research (09752366), 2020, p3707
- ISSN
0975-2366
- Publication type
Article
- DOI
10.31838/ijpr/2020.SP2.450