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- Title
COMPUTATIONAL ANALYSIS OF THERAPEUTIC POTENTIAL AND ANTI-ALZHEIMER'S EFFICACY OF MYRISTICIN FROM NUTMEG (MYRISTICA FRAGRANS).
- Authors
Thamaraiselvan, Selvendran; Arockiaraj, Sherlin Roshita; Jeyaseelan, Jeba Mercy; Antony Samy, Jose Vinoth Raja; Francis, Rahul; Tharumasivam, Siva Vijayakumar; Janani, Chandran
- Abstract
In our everyday lives, the brain is influenced by our lifestyles, and factors like an improper diet and stress can result in neurological impairment, causing malfunction in brain proteins. This phenomenon is associated with neurological disorders such as Alzheimer's, Parkinson's and Huntington's disease. Alzheimer's disease (AD) is particularly noteworthy as a widespread neurodegenerative disorder, prompting significant attention. Current pharmacological interventions targeting enzymes like Acetylcholinesterase (AChE), Beta-secretase (BACE1), Amine oxidase (AOs) and Presenilin 1 (PSEN1) often yield adverse side effects. This paper investigates the therapeutic potential of Myristicin, a natural bioactive compound found in Myristica fragrans (Nutmeg). Myristicin has a historical track record of providing beneficial effects, prompting a contemporary assessment of its properties, including antioxidant and antibacterial activities. To evaluate its efficacy, employ the computational methods for docking and toxicological assessments. The findings of our research indicate that myristicin demonstrates a notable binding capacity with enzymes associated with Alzheimer's disease. This suggests it's potential as a natural therapeutic alternative with minimal adverse effects compared to traditional chemical drugs. The computational toxicological evaluation suggests that myristicin does not pose significant adverse effects, emphasizing its potential safety profile. This research bridges historical knowledge of myristicin benefits with modern computational methods, shedding light on its potential in the complex landscape of Alzheimer's disease therapeutics. In our study presents myristicin as a promising candidate for further exploration in Alzheimer's disease treatment. The computational insights provided here pave the way for future research, contributing to the development of natural and effective therapies with reduced side effects in the realm of neurodegenerative disorders.
- Subjects
NUTMEG tree; ACETYLCHOLINESTERASE; ALZHEIMER'S disease; AMINE oxidase; PARKINSON'S disease; HUNTINGTON disease
- Publication
Biochemical & Cellular Archives, 2024, Vol 24, Issue 1, p1111
- ISSN
0972-5075
- Publication type
Article
- DOI
10.51470/bca.2024.24.1.1111