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- Title
THE RELATIONSHIP BETWEEN ASPROSIN AND SOME BIOMARKERS IN IRAQI ATHEROSCLEROSIS PATIENTS.
- Authors
Abdullah, Ghufran Saab; Alaaraji, Shakir F. T.
- Abstract
Cardiovascular disease (CVD), regardless of gender is the leading cause of death and disability in the world and atherosclerosis (AS) is a slow, multi-year disorder with symptoms that can begin in childhood or early thirties. Present study aims to determine the relationship between Asprosin (ASP) and Some Biomarkers in Iraqi AS Patients. This study was conducted in general education hospital in Ramadi of 50 AS patients Iraqi and 34 healthy controls, proportional to age and sex were included. Serum ASP concentrations were measured via a commercially available ELISA kit, while other variables estimated by colored enzymatic methods. The ASP concentration was clearly between AS patients and controls (P< 0.000l). Interestingly, the concentration of ASP was greater in AS patients compared to healthy controls, while urea, T.Cho, TG, LDL, VLDL, cTn-T, LDH-1 and FSG were importantly greater in AS patients than in HCs with (P< 0.000l) for these parameters. ASP has important negative correlation with HDL, Albumin, (P<0.001), also this study found that serum levels of ASP were correlated positively with, cTn-T, LDH_1, T.Cho, TG, LDL and VLDL, studied variables presented the following descending order of area under the receiver operating characteristic (AUROC), Tn-T (1), LDH-1 (0.9888), TG (0.9444), HDL (0.8565), ASP (0.8306), VLDL (0.7912), LDL (0.7585), FSG (0.7574), urea (0.7394), T.Cho (0.7183), creatinine (0.5846), TSP (0.5579), albumin (0.5544), globulins (0.5797). In conclusion, serum ASP is present in high levels in the blood serum of AS patients, where it can appear a dangerous part in the development of the disease and may be used in diagnosis and predicator of AS in Iraqi subjects.
- Subjects
RAMADI (Iraq); RECEIVER operating characteristic curves; BLOOD lipoproteins; BIOMARKERS; ATHEROSCLEROSIS; HIGH density lipoproteins; UREA
- Publication
Biochemical & Cellular Archives, 2022, Vol 22, Issue 1, p203
- ISSN
0972-5075
- Publication type
Article