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- Title
ANTI-TUMOR POTENTIAL OF SOME NEW SYNTHETIZED DIHYDROXAMIC COMPOUNDS.
- Authors
Petreus, T.; Cotrutz, Carmen Elena; Neamtu, A.; Oprea, Ana-Maria; Barbu-Tudoran, L.; Zlei, Mihaela; Goriuc, Ancuta; Peptanariu, D.
- Abstract
Matrix metalloproteinases (MMP) are a class of structural and functional related enzymes involved in altering the natural elements of the extracellular matrix. The aim of our study was to evaluate the inhibition ability of three new synthetized anti-MMP agents against the proliferating malignant cells and also their hemotoxicity. We have synthesized three new hydroxamic compounds in order to test their antitumoral capacity. Actually our tested compounds are dihydroxamic acid salts, denominated as ACDH - acetyl dihydroxamic acid, DHA - adypoil dihydroxamic acid and DHT - terephtaloil dihydroxamic acid. Hemolysis test results are shown in table 1 and figure 2. For all tested synthetic inhibitors, the hemolysed percent was less than 1% by comparison with positive witness; these values are under the 5% limit imposed by the ISO10993-4:2002 standard. We have observed that the new synthetized inhibitors have induced a moderate reduction of the L-363 cells proliferation rate. The only water soluble inhibitor shown a reduced rate of tumor cell proliferation rate decrease. DHT has reduced the multiplication rate for these malignant cells. The main idea is to produce some inhibitors for MMP activity, moreover some MMP activity modulators than tumoricide agents.
- Subjects
METALLOPROTEINASES; HEMOLYSIS &; hemolysins; ENZYMES; EXTRACELLULAR matrix; RESPONSE inhibition; CELL proliferation; HYDROXAMIC acids; CANCER cells
- Publication
Annals of the Romanian Society for Cell Biology, 2010, Vol 15, Issue 2, p368
- ISSN
2067-3019
- Publication type
Article