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- Title
Cytokine expression in cancer patients suffering from chronic pain: A systematic review.
- Authors
De Groote, A.; Vyvere, T. Vande; De Groef, A.; Meeus, M.
- Abstract
Introduction: Chronic pain during and after cancer treatment is a commonly underdiagnosed and undertreated symptom. Recent insights suggest the immune system, e.g., cytokine signaling, plays an important role in the development and maintenance of persistent pain. In (non-cancer) patients without pain, differences in cytokine expression have already been observed compared to controls. However, it is less clear how cytokine expression relates to chronic pain in cancer patients. The goal of this study is to systematically review the literature and to investigate cytokine expression between cancer patients with chronic pain and healthy volunteers or patients without pain. Methods: To retrieve studies, a systematic literature search will be conducted in PubMed, Web of Science, and Embase. Data deduplication, screening, and extraction will be performed by two independent reviewers using Covidence. Risk of bias will be evaluated using the Newcastle-Ottawa Scale. When possible, a meta-analysis will be conducted otherwise data will be presented as a narrative summary. Heterogeneity will be evaluated using the Chi² test and I² test. Results: It is expected that cancer patients with chronic pain show persisting differences in cytokine expression after cancer treatment that contribute to their chronic pain experience. Specific results will follow upon data synthesis. Process evaluation: The broad and sensitive literature search provided 3045 articles to screen, containing a lot of noise.
- Subjects
NETHERLANDS; CHRONIC pain; CYTOKINES; CONFERENCES &; conventions; CANCER patients; GENE expression
- Publication
Pain Practice, 2022, Vol 22, p26
- ISSN
1530-7085
- Publication type
Article
- DOI
10.1111/papr.13128