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- Title
A QST‐based Pain Phenotype in Adults With Sickle Cell Disease: Sensitivity and Specificity of Quality Descriptors.
- Authors
Dyal, Brenda W.; Ezenwa, Miriam O.; Yoon, Saunjoo L.; Fillingim, Roger B.; Yao, Yingwei; Schlaeger, Judith M.; Suarez, Marie L.; Wang, Zaijie J.; Molokie, Robert E.; Wilkie, Diana J.
- Abstract
Background: We sought to refine a screening measure for discriminating a sensitized or normal sensation pain phenotype among African American adults with sickle cell disease (SCD). Objective: To develop scoring schemes based on sensory pain quality descriptors; evaluate their performance on classifying patients with SCD who had sensitization or normal sensation, and compare with scores on the Self‐report Leeds Assessment of Neuropathic Symptoms and Signs (S‐LANSS) and the Neuropathic Pain Symptom Inventory (NPSI). Methods: Participants completed PAINReportIt, quantitative sensory testing (QST), S‐LANSS, and NPSI. Conventional binary logistic regression and least absolute shrinkage and selection operator (lasso) regression were used to obtain 2 sets of weights resulting in 2 scores: the PR‐Logistic (PAINReportIt score weighted by conventional binary logistic regression coefficients) and PR‐Lasso (PAINReportIt score weighted by lasso regression coefficients). Performance of the proposed scores and the existing scores were evaluated. Results: Lasso regression resulted in a parsimonious model with non‐zero weights assigned to 2 neuropathic descriptors, cold and spreading. We found positive correlations between the PR‐Lasso and other scores: S‐LANSS (r = 0.22, P < 0.01), NPSI (r = 0.22, P < 0.01), and PR‐Logistic (r = 0.35, P < 0.01). The NPSI and PR‐Lasso performed similarly at different levels of required specificity and outperformed the S‐LANSS and PR‐Logistic at the various specificity points. Conclusion: The PR‐Lasso offers a way to discriminate a SCD pain phenotype.
- Subjects
NEURALGIA; SICKLE cell anemia; PHENOTYPES; LOGISTIC regression analysis; PAIN measurement; PAIN threshold; DISEASE complications; ADULTS
- Publication
Pain Practice, 2020, Vol 20, Issue 2, p168
- ISSN
1530-7085
- Publication type
Article
- DOI
10.1111/papr.12841