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- Title
In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam.
- Authors
VanNatta, Mollie; Grier, Laurie; Khan, Muhammad H; Cornejo, Paulette Pinargote; Alam, Mohammad; Moussa, Samir H; Smith, Jennifer G; Aitken, Samuel L; Malek, Alexandre E
- Abstract
The treatment of patients with infection secondary to carbapenem-resistant Acinetobacter baumannii with emerging cefiderocol resistance remains challenging and unclear. We present a case of in vivo emergence of pandrug-resistant A baumannii that was successfully treated with the compassionate use of investigational sulbactam-durlobactam–based antibiotic regimen. We also performed a longitudinal genomic analysis of the bacterial isolates and showed the development of resistance and genetic mutations over time.
- Subjects
ACINETOBACTER baumannii; CARBAPENEM-resistant bacteria; GENOMICS; GENETIC mutation; TREATMENT effectiveness
- Publication
Open Forum Infectious Diseases, 2023, Vol 10, Issue 10, p1
- ISSN
2328-8957
- Publication type
Case Study
- DOI
10.1093/ofid/ofad504