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- Title
A drug–drug cocrystal and a co‐amorphous form, prepared from honokiol and ligustrazine, inspired by Chinese patent medicine.
- Authors
Zhang, Yanli; Liu, Hui; Chen, Zongxin; Meng, Jialei; Li, Yunfeng; Qi, Luyao; Zhang, Suiliang; Chen, Xiaofeng; Lei, Ming
- Abstract
A drug–drug cocrystal created with two antithrombotic‐active ingredients from herbs, honokiol (HON) and ligustrazine (TMP, 1:1), was synthesized and characterized. The structure of HON–TMP (1:1) was determined by single‐crystal X‐ray diffraction. Then co‐amorphous HON–TMP was prepared by honey‐assisted grinding, which was inspired by a grinding process for a Chinese patent medicine‐Shijunzi honey pill. This co‐amorphous drug–drug cocrystal (20% honey) exhibits improved solubility over HON and a significantly reduced sublimation tendency than TMP.
- Subjects
CHINESE medicine; DRUG solubility; X-ray diffraction; HONEY; DRUG interactions
- Publication
Acta Crystallographica Section B: Structural Science, Crystal Engineering & Materials, 2023, Vol 79, Issue 6, p519
- ISSN
2052-5192
- Publication type
Article
- DOI
10.1107/S2052520623008648