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- Title
Vitamin D status and obesity in children from Chile.
- Authors
Pérez-Bravo, Francisco; Duarte, Lissette; Arredondo-Olguín, Miguel; Iñiguez, Germán; Castillo-Valenzuela, Oscar
- Abstract
<bold>Background: </bold>Vitamin D [25(OH)D] is essential for normal bone development and maintenance. Furthermore, its deficiency has been associated with obesity, cardiovascular diseases, insulin resistance, autoimmune diseases, and certain cancers.<bold>Objective: </bold>To determine the incidence of serum 25(OH)D deficiency (<20 ng/ml) among apparently healthy Chilean children (4-14 years old) from three Chilean geographic areas during May-September 2018.<bold>Materials and Methods: </bold>Serum 25(OH)D levels were measured by a competitive protein-binding ELISA assay in 1134 children, and correlations between serum 25(OH)D levels, BMI, and geographic area were calculated. Individuals were grouped according to their serum 25-hydroxyvitamin D levels (ng/ml): severe deficiency: <5; moderate deficiency: 5-10.9; mild deficiency: 11-20.9; insufficiency: 21-29.9 and sufficiency: 30-100.<bold>Results: </bold>We found 80.4% of children had serum 25(OH)D deficiency, with 1.7% severe, 24.6% moderate, and 54.1% mild. In the three cities, the percentage of serum 25(OH)D deficit was increased when comparing overweight or obesity with a healthy weight. Additionally, an interaction effect was observed between geographic area, nutritional status, and serum 25(OH)D levels using the factorial ANOVA test (p = 0.038). In Antofagasta, there were more overweight children and also a higher percentage of children with VitD deficiency (<30 ng/ml) compared to Santiago or Concepción.<bold>Conclusion: </bold>This study revealed a high prevalence of serum 25(OH)D deficiency in children between 4 and 14 years old in Chile (80.4%) during May-September 2018. Obese and overweight children had the highest prevalence of serum 25(OH)D deficiency.
- Publication
European Journal of Clinical Nutrition, 2022, Vol 76, Issue 6, p899
- ISSN
0954-3007
- Publication type
journal article
- DOI
10.1038/s41430-021-01043-9