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- Title
A shared mechanism of SoxR activation by redox-cycling compounds.
- Authors
Dietrich, Lars E. P.; Kiley, Patricia J.
- Abstract
In this issue of Molecular Microbiology, Gu and Imlay show that a class of compounds known as redox-cycling agents directly activate the transcription factor SoxR of Escherichia coli and cause cellular toxicity independent of the production of the reactive oxygen species superoxide. Despite the fact that redox-cycling agents increase formation of superoxide in E. coli, the results described in this new publication revise the long-held assumption that superoxide is responsible for the activation of SoxR and for all of the major toxic effects of redox-cycling drugs. This study also suggests that the critical function of the SoxRS regulon in E. coli is in protection against redox-cycling agents and not exclusively the defence against superoxide.
- Subjects
OXIDATION-reduction reaction; TRANSCRIPTION factors; SUPEROXIDES; ESCHERICHIA coli; ESCHERICHIA coli diseases
- Publication
Molecular Microbiology, 2011, Vol 79, Issue 5, p1119
- ISSN
0950-382X
- Publication type
Article
- DOI
10.1111/j.1365-2958.2011.07552.x