We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fatal carboplatin-induced immune hemolytic anemia in a child with a brain tumor.
- Authors
Haley, Kristina M.; Russell, Thomas B.; Boshkov, Lynn; Leger, Regina M.; Garratty, George; Recht, Michael; Nazemi, Kellie J.
- Abstract
Drug-induced immune hemolytic anemia (DIIHA) is an uncommon side effect of pharmacologic intervention. A rare mediator of DIIHA, carboplatin is an agent used to treat many pediatric cancers. We describe here, the first case of fatal carboplatin induced DIIHA in a pediatric patient and a brief review of the literature. Our patient developed acute onset of multi-organ failure with evidence of complement activation, secondary to a drug induced red cell antibody. Early recognition of the systemic insult associated with carboplatin induced hemolytic anemia may allow for future affected patients to receive plasmapheresis, a potentially effective therapy.
- Subjects
CARBOPLATIN; CHILDHOOD cancer; COMPLEMENT fixation; PLASMAPHERESIS; HEMOLYTIC anemia; ERYTHROCYTES
- Publication
Journal of Blood Medicine, 2014, Vol 5, p55
- ISSN
1179-2736
- Publication type
Article
- DOI
10.2147/JBM.S59192