We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D<sub>1</sub> and hypoxia-inducible factor-1a (HIF-1a).
- Authors
Bos, Reinhard; Van Diest, Paul J; Van der Groep, Petra; Greijer, Astrid E; Hermsen, Mario AJA; Heijnen, Ingrid; Meijer, Gerrit A; Baak, Jan PA; Pinedo, Herbert M; Van der Wall, Elsken; Shvarts, Avi
- Abstract
B-cell lymphoma gene (BCL-6) upregulation contributes to immortalization of mouse embryo fibroblast and primary B cells via upregulation of cyclin D1. As cyclin D1 overexpression is a common phenomenon in different cancers, BCL-6 protein overexpression may not be restricted to lymphomas. In this study, expression of BCL-6 was investigated by immunohistochemistry on paraffin-embedded specimens from 150 breast cancer patients and 10 specimens of normal breast tissue. The results showed BCL-6 overexpression (?10% of cells) in 24/150 (16%) breast cancer patients, whereas in normal breast low expression (<1%) of BCL-6 was observed. In linear regression analysis BCL-6 expression was associated with cyclin D1 (r=0.197, P=0.016). Further, in ?2 analyses, BCL-6-positivity was associated with overexpression of p53 (P=0.016), and hypoxia-inducible factor-1a (P<0.001). Involvement of BCL-6 in breast carcinogenesis is further underscored by comparative genomic hybridization analysis that showed gains at the BCL-6 locus (3q27) in 14/86 (16%) breast cancer tissues. The cases with amplification in BCL-6 showed an increased (25%) incidence of BCL-6 protein overexpression. Thus, this study is the first to show that BCL-6 oncogene activation plays a role in cancers other than lymphomas.Oncogene (2003) 22, 8948-8951. doi:10.1038/sj.onc.1206995
- Subjects
PROTEINS; GENE expression; B cells; LYMPHOMAS; HYPOXEMIA
- Publication
Oncogene, 2003, Vol 22, Issue 55, p8948
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1206995