We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Myocilin and optineurin: Differential characteristics and functional consequences
- Authors
Yue, Beatrice Y.J.T.
- Abstract
Abstract: Myocilin and optineurin are two genes linked to glaucoma, a major blinding disease characterized by progressive loss of retinal ganglion cells and their axons. This review describes the characteristics of myocilin and optineurin protein products and summarizes the consequences of ectopically expressed wild-type and mutant myocilin and optineurin in trabecular meshwork and/or neuronal cells. Myocilin and optineurin exhibit differential characteristics and have divergent functional consequences. They contribute to the development of glaucoma probably via distinct mechanisms.
- Subjects
EYE diseases; MYOCILIN; GLAUCOMA; BLINDNESS; RETINAL ganglion cells; NEURAL stem cells
- Publication
Taiwan Journal of Ophthalmology, 2011, Vol 1, Issue 1, p6
- ISSN
2211-5056
- Publication type
Article
- DOI
10.1016/j.tjo.2011.08.002