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- Title
Early Intervention with Adalimumab May Contribute to Favorable Clinical Efficacy in Patients with Crohn's Disease.
- Authors
Miyoshi, Jun; Hisamatsu, Tadakazu; Matsuoka, Katsuyoshi; Naganuma, Makoto; Maruyama, Yuriko; Yoneno, Kazuaki; Mori, Kiyoto; Kiyohara, Hiroki; Nanki, Kosaku; Okamoto, Susumu; Yajima, Tomoharu; Iwao, Yasushi; Ogata, Haruhiko; Hibi, Toshifumi; Kanai, Takanori
- Abstract
Background: We evaluated the clinical efficacy of adalimumab (ADA) for Crohn's disease (CD) and analyzed predictive factors for clinical remission and long-term prognosis. Methods: We retrospectively reviewed the medical records of 45 patients treated with ADA for CD at Keio University Hospital between October 2010 and March 2014. Clinical remission was defined as a Harvey-Bradshaw index of ≤4. Results: Twenty-eight of 45 patients (62.2%) achieved clinical remission at week 4. Among these 28 patients, 18 patients (64.3%) maintained clinical remission at week 26, and among these, 16 patients (88.9%) maintained clinical remission at week 52. Absence of a history of bowel resection and absence of prior anti-tumor necrosis factor (anti-TNF) therapy were significant predictive factors for clinical remission at week 4 upon multivariate logistic regression analyses. Younger age and a disease duration of ≤3 years correlated with clinical remission at week 26 upon univariate analyses. Patients without a history of bowel resection showed significantly better long-term prognosis than those with a history of bowel resection (p = 0.01). None of the patients contracted a serious infectious disease. Conclusions: Younger age, shorter duration of disease, being naive to anti-TNF antagonists, and absence of a history of bowel resection were associated with the efficacy of ADA in CD patients. © 2014 S. Karger AG, Basel
- Subjects
INFLAMMATORY bowel disease treatment; ADALIMUMAB; DRUG efficacy; TREATMENT effectiveness; TUMOR necrosis factors; DISEASE duration; THERAPEUTICS
- Publication
Digestion, 2014, Vol 90, Issue 2, p130
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000365783