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- Title
The Influence of Pioglitazone Administration on The Protection Against Alzheimer's Disease- Induced Apoptosis in Human Umbilical Vein Endothelial Cells.
- Authors
Tahani, S.; Dehghani, L.; Meamar, R.; Saadatniar, M; Nasr Esfahani, M. H.
- Abstract
Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease which endothelial cell (EC) can be affected by these diseases. Peroxisome proliferator- activated receptor- γ (PPAR-γ) agonists (thiazolidinediones, TZDs) such as pioglitazone (PIO) has potent anti-inflammatory property, but increasing evidence suggests that these drugs also improve vascular function and prevent atherosclerotic disease progression. Materials and Methods: Human umbilical vein endothelial cells (HUVECs) were treated with sera from AD patients (n = 20) and sera from controls (n = 10). Apoptosis was identified by annexin V-propidium iodide staining and cell death detection kit. Apoptosis was evaluated after and before adding of 10μM pioglitazone on EC. Results: Induced apoptosis by the serum of patients inhibit markedly when Pioglitazone used before treating HUVECs with the sera of AD. Conclusion: Further studies are justified to investigate the novel role of the PPARs in the prevention of the neuronal and endothelial damage in neurological disorder and present a new therapeutic approach for Alzheimer's patients
- Subjects
ALZHEIMER'S disease diagnosis; ENDOTHELIAL cells; PEROXISOMES; ANNEXINS; PIOGLITAZONE
- Publication
Cell Journal (Yakhteh), 2013, Vol 15, Issue Sup 1, p27
- ISSN
2228-5806
- Publication type
Article